Ontology highlight
ABSTRACT:
SUBMITTER: Sarradin P
PROVIDER: S-EPMC4527776 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Sarradin Pierre P Viglietta Céline C Limouzin Claude C Andréoletti Olivier O Daniel-Carlier Nathalie N Barc Céline C Leroux-Coyau Mathieu M Berthon Patricia P Chapuis Jérôme J Rossignol Christelle C Gatti Jean-Luc JL Belghazi Maya M Labas Valérie V Vilotte Jean-Luc JL Béringue Vincent V Lantier Frédéric F Laude Hubert H Houdebine Louis-Marie LM
PLoS pathogens 20150806 8
Transmissible spongiform encephalopathies (TSEs) are a group of neurodegenerative diseases affecting a wide range of mammalian species. They are caused by prions, a proteinaceous pathogen essentially composed of PrPSc, an abnormal isoform of the host encoded cellular prion protein PrPC. Constrained steric interactions between PrPSc and PrPC are thought to provide prions with species specificity, and to control cross-species transmission into other host populations, including humans. Transgenetic ...[more]