Ontology highlight
ABSTRACT:
SUBMITTER: Schneider D
PROVIDER: S-EPMC4528117 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Schneider Daniel D Kaiser Wolfgang W Stutz Cian C Holinski Alexandra A Mayans Olga O Babinger Patrick P
The Journal of biological chemistry 20150610 32
We present the crystal structure and biochemical characterization of Escherichia coli YbiB, a member of the hitherto uncharacterized TrpD2 protein family. Our results demonstrate that the functional diversity of proteins with a common fold can be far greater than predictable by computational annotation. The TrpD2 proteins show high structural homology to anthranilate phosphoribosyltransferase (TrpD) and nucleoside phosphorylase class II enzymes but bind with high affinity (KD = 10-100 nM) to nuc ...[more]