Microbuckling of fibrin provides a mechanism for cell mechanosensing.
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ABSTRACT:
SUBMITTER: Notbohm J
PROVIDER: S-EPMC4528600 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Publications
Microbuckling of fibrin provides a mechanism for cell mechanosensing.
Notbohm Jacob J Lesman Ayelet A Rosakis Phoebus P Tirrell David A DA Ravichandran Guruswami G
Journal of the Royal Society, Interface 20150701 108
Biological cells sense and respond to mechanical forces, but how such a mechanosensing process takes place in a nonlinear inhomogeneous fibrous matrix remains unknown. We show that cells in a fibrous matrix induce deformation fields that propagate over a longer range than predicted by linear elasticity. Synthetic, linear elastic hydrogels used in many mechanotransduction studies fail to capture this effect. We develop a nonlinear microstructural finite-element model for a fibre network to simula ...[more]
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