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A boundary-integral representation for biphasic mixture theory, with application to the post-capillary glycocalyx.

ABSTRACT: We describe a new boundary-integral representation for biphasic mixture theory, which allows us to efficiently solve certain elastohydrodynamic-mobility problems using boundary element methods. We apply this formulation to model the motion of a rigid particle through a microtube which has non-uniform wall shape, is filled with a viscous Newtonian fluid, and is lined with a thin poroelastic layer. This is relevant to scenarios such as the transport of small rigid cells (such as neutrophils) through microvessels that are lined with an endothelial glycocalyx layer (EGL). In this context, we examine the impact of geometry upon some recently reported phenomena, including the creation of viscous eddies, fluid flux into the EGL, as well as the role of the EGL in transmitting mechanical signals to the underlying endothelial cells.

SUBMITTER: Sumets PP

PROVIDER: S-EPMC4528650 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

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A boundary-integral representation for biphasic mixture theory, with application to the post-capillary glycocalyx.

Sumets P P PP Cater J E JE Long D S DS Clarke R J RJ

Proceedings. Mathematical, physical, and engineering sciences 20150701 2179

We describe a new boundary-integral representation for biphasic mixture theory, which allows us to efficiently solve certain elastohydrodynamic-mobility problems using boundary element methods. We apply this formulation to model the motion of a rigid particle through a microtube which has non-uniform wall shape, is filled with a viscous Newtonian fluid, and is lined with a thin poroelastic layer. This is relevant to scenarios such as the transport of small rigid cells (such as neutrophils) throu ...[more]

PMID: 26345494

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