Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndrome.
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ABSTRACT:
SUBMITTER: Wu H
PROVIDER: S-EPMC4528928 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndrome.
Wu Hong H Zeng Hong H Lam Robert R Tempel Wolfram W Kerr Iain D ID Min Jinrong J
Acta crystallographica. Section F, Structural biology communications 20150728 Pt 8
Mismatch repair prevents the accumulation of erroneous insertions/deletions and non-Watson-Crick base pairs in the genome. Pathogenic mutations in the MLH1 gene are associated with a predisposition to Lynch and Turcot's syndromes. Although genetic testing for these mutations is available, robust classification of variants requires strong clinical and functional support. Here, the first structure of the N-terminus of human MLH1, determined by X-ray crystallography, is described. The structure sha ...[more]
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