Ontology highlight
ABSTRACT:
SUBMITTER: Kudlinzki D
PROVIDER: S-EPMC4528947 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Acta crystallographica. Section F, Structural biology communications 20150729 Pt 8
Protein kinases (PKs) are dynamic regulators of numerous cellular processes. Their phosphorylation activity is determined by the conserved kinase core structure, which is maintained by the interaction and dynamics with associated domains or interacting proteins. The prototype enzyme for investigations to understand the activity and regulation of PKs is the catalytic subunit of cAMP-dependent protein kinase (PKAc). Major effects of functional regulation and ligand binding are driven by only minor ...[more]