Ontology highlight
ABSTRACT:
SUBMITTER: Li-Villarreal N
PROVIDER: S-EPMC4529026 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Li-Villarreal Nanbing N Forbes Meredyth M MM Loza Andrew J AJ Chen Jiakun J Ma Taylur T Helde Kathryn K Moens Cecilia B CB Shin Jimann J Sawada Atsushi A Hindes Anna E AE Dubrulle Julien J Schier Alexander F AF Longmore Gregory D GD Marlow Florence L FL Solnica-Krezel Lilianna L
Development (Cambridge, England) 20150709 15
Dachsous (Dchs), an atypical cadherin, is an evolutionarily conserved regulator of planar cell polarity, tissue size and cell adhesion. In humans, DCHS1 mutations cause pleiotropic Van Maldergem syndrome. Here, we report that mutations in zebrafish dchs1b and dchs2 disrupt several aspects of embryogenesis, including gastrulation. Unexpectedly, maternal zygotic (MZ) dchs1b mutants show defects in the earliest developmental stage, egg activation, including abnormal cortical granule exocytosis (CGE ...[more]