Biodegradable nanoellipsoidal artificial antigen presenting cells for antigen specific T-cell activation.
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ABSTRACT:
SUBMITTER: Meyer RA
PROVIDER: S-EPMC4529071 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
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Biodegradable nanoellipsoidal artificial antigen presenting cells for antigen specific T-cell activation.
Meyer Randall A RA Sunshine Joel C JC Perica Karlo K Kosmides Alyssa K AK Aje Kent K Schneck Jonathan P JP Green Jordan J JJ
Small (Weinheim an der Bergstrasse, Germany) 20150112 13
Non-spherical nanodimensional artificial antigen presenting cells (naAPCs) offer the potential to systemically induce an effective antigen-specific immune response. In this report it is shown biodegradable ellipsoidal naAPCs mimic the T-Cell/APC interaction better than equivalent spherical naAPCs. In addition, it is demonstrated ellipsoidal naAPCs offer reduced non-specific cellular uptake and a superior pharmacokinetic profile compared to spherical naAPCs. ...[more]
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