Ontology highlight
ABSTRACT:
SUBMITTER: Ramsey LB
PROVIDER: S-EPMC4529108 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Ramsey Laura B LB Janke Laura J LJ Payton Monique A MA Cai Xiangjun X Paugh Steven W SW Karol Seth E SE Kamdem Kamdem Landry L Cheng Cheng C Williams Richard T RT Jeha Sima S Pui Ching-Hon CH Evans William E WE Relling Mary V MV
PloS one 20150807 8
Osteonecrosis is one of the most common, serious, toxicities resulting from the treatment of acute lymphoblastic leukemia. In recent years, pediatric acute lymphoblastic leukemia clinical trials have used discontinuous rather than continuous dosing of dexamethasone in an effort to reduce the incidence of osteonecrosis. However, it is not known whether discontinuous dosing would compromise antileukemic efficacy of glucocorticoids. Therefore, we tested the efficacy of discontinuous dexamethasone a ...[more]