Age, atherosclerosis and type 2 diabetes reduce human mesenchymal stromal cell-mediated T-cell suppression.
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ABSTRACT:
SUBMITTER: Kizilay Mancini O
PROVIDER: S-EPMC4529693 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
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Age, atherosclerosis and type 2 diabetes reduce human mesenchymal stromal cell-mediated T-cell suppression.
Kizilay Mancini Ozge O Shum-Tim Dominique D Stochaj Ursula U Correa José A JA Colmegna Inés I
Stem cell research & therapy 20150808
To this end human MSCs were isolated from adipose tissue and the MSC:CD4(+) T-cell suppression was assessed in a co-culture system. In summary, this study demonstrates that advanced age, atherosclerosis and type 2 diabetes mellitus reduce the functional potency of MSCs. Optimizing the criteria for the selection of MSC donors could enhance the results of cell-based therapies. ...[more]
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