Ontology highlight
ABSTRACT:
SUBMITTER: Hong E
PROVIDER: S-EPMC4529905 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Hong Elaine E Best Andrew A Gautrey Hannah H Chin Jas J Razdan Anshuli A Curk Tomaz T Elliott David J DJ Tyson-Capper Alison J AJ
BioMed research international 20150726
Scaffold attachment factor B1 (SAFB1) and SAFB2 proteins are oestrogen (ER) corepressors that bind to and modulate ER activity through chromatin remodelling or interaction with the basal transcription machinery. SAFB proteins also have an internal RNA-recognition motif but little is known about the RNA-binding properties of SAFB1 or SAFB2. We utilised crosslinking and immunoprecipitation (iCLIP) coupled with high-throughput sequencing to enable a transcriptome-wide mapping of SAFB1 protein-RNA i ...[more]