Dataset Information

Heart rate variability and the risk of Parkinson disease: The Atherosclerosis Risk in Communities study.

ABSTRACT:

Objective

Autonomic dysfunction frequently occurs in the context of Parkinson disease (PD) and may precede onset of motor symptoms. Limited data exist on the prospective association of heart rate variability (HRV), a marker of autonomic function, with PD risk.

Methods

We included 12,162 participants of the Atherosclerosis Risk in Communities study, a community-based cohort, without a diagnosis of PD at baseline (1987-1989) and with available HRV data (mean age = 54 years, 57% women). A 2-minute electrocardiogram was used to measure HRV. Incident PD was identified through 2008 from multiple sources, and adjudicated. Multivariable Cox models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of PD by quartiles of HRV measurements.

Results

During a mean follow-up of 18 years, we identified 78 incident PD cases. Lower values of the root mean square of successive differences in normal-to-normal R-R intervals (rMSSD) and standard deviation of normal-to-normal R-R intervals (SDNN), markers of parasympathetic activity and total variability, respectively, were associated with higher PD risk during follow-up. In multivariate models, the HR (95% CI) of PD in the bottom quartiles of rMSSD and SDNN compared to the top quartiles were 2.1 (1.0-4.3) and 2.9 (1.4-6.1), respectively. Other measures of cardiac autonomic function, including mean R-R interval and frequency-domain measurements, were not associated with PD risk.

Interpretation

In this prospective cohort, decreased HRV was associated with an increased risk of PD. Assessment of cardiac autonomic function may help identify individuals at risk for PD.

SUBMITTER: Alonso A

PROVIDER: S-EPMC4529999 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature

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Publications

Heart rate variability and the risk of Parkinson disease: The Atherosclerosis Risk in Communities study.

Alonso Alvaro A Huang Xuemei X Mosley Thomas H TH Heiss Gerardo G Chen Honglei H

Annals of neurology 20150327 5

<h4>Objective</h4>Autonomic dysfunction frequently occurs in the context of Parkinson disease (PD) and may precede onset of motor symptoms. Limited data exist on the prospective association of heart rate variability (HRV), a marker of autonomic function, with PD risk.<h4>Methods</h4>We included 12,162 participants of the Atherosclerosis Risk in Communities study, a community-based cohort, without a diagnosis of PD at baseline (1987-1989) and with available HRV data (mean age = 54 years, 57% wome ...[more]

PMID: 25707861

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Dataset Information

Heart rate variability and the risk of Parkinson disease: The Atherosclerosis Risk in Communities study.

Objective

Methods

Results

Interpretation

Publications

Heart rate variability and the risk of Parkinson disease: The Atherosclerosis Risk in Communities study.

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