Ontology highlight
ABSTRACT:
SUBMITTER: Farkas AE
PROVIDER: S-EPMC4530128 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Farkas Attila E AE Hilgarth Roland S RS Capaldo Christopher T CT Gerner-Smidt Christian C Powell Doris R DR Vertino Paula M PM Koval Michael M Parkos Charles A CA Nusrat Asma A
The American journal of pathology 20150801 8
The intestinal epithelium is a dynamic barrier that maintains the distinct environments of intestinal tissue and lumen. Epithelial barrier function is defined principally by tight junctions, which, in turn, depend on the regulated expression of claudin family proteins. Claudins are expressed differentially during intestinal epithelial cell (IEC) differentiation. However, regulatory mechanisms governing claudin expression during epithelial differentiation are incompletely understood. We investiga ...[more]