Ontology highlight
ABSTRACT:
SUBMITTER: Kolovou G
PROVIDER: S-EPMC4530653 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Kolovou Genovefa G Kolovou Vana V Ragia Georgia G Mihas Constantinos C Diakoumakou Olga O Vasiliadis Ioannis I Mavrogeni Sophie S Vartela Vassiliki V Manolopoulos Vangelis G VG
Genetics and molecular biology 20150501 2
In this work, we examined the impact of polymorphism in the cytochrome P450 (CYP) 3A5 gene, CYP3A5*1 (6986A > G, rs 776746), on the reduction in the lipid levels caused by simvastatin and atorvastatin. We studied 350 hyperlipidemic patients who received 10-40 mg of atorvastatin (n = 175) or simvastatin (n = 175) daily. Genotyping for CYP3A5 was done by PCR-RFLP analysis. Differences in the lipid profile before and after treatment were expressed as the % difference. The frequency of CYP3A5polymor ...[more]