Ontology highlight
ABSTRACT:
SUBMITTER: Holohan B
PROVIDER: S-EPMC4531080 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Holohan Brody B De Meyer Tim T Batten Kimberly K Mangino Massimo M Hunt Steven C SC Bekaert Sofie S De Buyzere Marc L ML Rietzschel Ernst R ER Spector Tim D TD Wright Woodring E WE Shay Jerry W JW
Aging cell 20150507 4
Telomere length shortens with aging, and short telomeres have been linked to a wide variety of pathologies. Previous studies suggested a discrepancy in age-associated telomere shortening rate estimated by cross-sectional studies versus the rate measured in longitudinal studies, indicating a potential bias in cross-sectional estimates. Intergenerational changes in initial telomere length, such as that predicted by the previously described effect of a father's age at birth of his offspring (FAB), ...[more]