Ontology highlight
ABSTRACT:
SUBMITTER: Reese TA
PROVIDER: S-EPMC4531374 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Reese T A TA Wakeman B S BS Choi H S HS Hufford M M MM Huang S C SC Zhang X X Buck M D MD Jezewski A A Kambal A A Liu C Y CY Goel G G Murray P J PJ Xavier R J RJ Kaplan M H MH Renne R R Speck S H SH Artyomov M N MN Pearce E J EJ Virgin H W HW
Science (New York, N.Y.) 20140626 6196
Mammals are coinfected by multiple pathogens that interact through unknown mechanisms. We found that helminth infection, characterized by the induction of the cytokine interleukin-4 (IL-4) and the activation of the transcription factor Stat6, reactivated murine γ-herpesvirus infection in vivo. IL-4 promoted viral replication and blocked the antiviral effects of interferon-γ (IFNγ) by inducing Stat6 binding to the promoter for an important viral transcriptional transactivator. IL-4 also reactivat ...[more]