Ontology highlight
ABSTRACT:
SUBMITTER: Ban L
PROVIDER: S-EPMC4531505 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Ban Liqin L Kuhtreiber Willem W Butterworth John J Okubo Yoshiaki Y Vanamee Éva S ÉS Faustman Denise L DL
Molecular and cellular therapies 20150812
<h4>Background</h4>Soluble TNF superfamily (TNFSF) ligands are less stable and less active than their transmembrane (tm) analogues. This is a problem for the therapeutic use of recombinant TNFSF ligands in diverse diseases including cancer and autoimmunity. Creating TNFSF ligand analogues with improved targeting of their respective receptors is important for research and therapeutic purposes.<h4>Findings</h4>Covalent internal cross-linking of TNF monomers by double mutations, S95C/G148C, results ...[more]