Microbial Ligand Costimulation Drives Neutrophilic Steroid-Refractory Asthma.
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ABSTRACT:
SUBMITTER: Hadebe S
PROVIDER: S-EPMC4532492 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Microbial Ligand Costimulation Drives Neutrophilic Steroid-Refractory Asthma.
Hadebe Sabelo S Kirstein Frank F Fierens Kaat K Chen Kong K Drummond Rebecca A RA Vautier Simon S Sajaniemi Sara S Murray Graeme G Williams David L DL Redelinghuys Pierre P Reinhart Todd A TA Fallert Junecko Beth A BA Kolls Jay K JK Lambrecht Bart N BN Brombacher Frank F Brown Gordon D GD
PloS one 20150811 8
Asthma is a heterogeneous disease whose etiology is poorly understood but is likely to involve innate responses to inhaled microbial components that are found in allergens. The influence of these components on pulmonary inflammation has been largely studied in the context of individual agonists, despite knowledge that they can have synergistic effects when used in combination. Here we have explored the effects of LPS and β-glucan, two commonly-encountered microbial agonists, on the pathogenesis ...[more]
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