Ontology highlight
ABSTRACT:
SUBMITTER: Visconti R
PROVIDER: S-EPMC4532778 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Cell death and differentiation 20150306 9
To grant faithful chromosome segregation, the spindle assembly checkpoint (SAC) delays mitosis exit until mitotic spindle assembly. An exceedingly prolonged mitosis, however, promotes cell death and by this means antimicrotubule cancer drugs (AMCDs), that impair spindle assembly, are believed to kill cancer cells. Despite malformed spindles, cancer cells can, however, slip through SAC, exit mitosis prematurely and resist killing. We show here that the Fcp1 phosphatase and Wee1, the cyclin B-depe ...[more]