Ontology highlight
ABSTRACT:
SUBMITTER: Russell R
PROVIDER: S-EPMC4532798 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Russell Ronan R Perkhofer Lukas L Liebau Stefan S Lin Qiong Q Lechel André A Feld Fenja M FM Hessmann Elisabeth E Gaedcke Jochen J Güthle Melanie M Zenke Martin M Hartmann Daniel D von Figura Guido G Weissinger Stephanie E SE Rudolph Karl-Lenhard KL Möller Peter P Lennerz Jochen K JK Seufferlein Thomas T Wagner Martin M Kleger Alexander A
Nature communications 20150729
Pancreatic ductal adenocarcinoma (PDAC) is associated with accumulation of particular oncogenic mutations and recent genetic sequencing studies have identified ataxia telangiectasia-mutated (ATM) mutations in PDAC cohorts. Here we report that conditional deletion of ATM in a mouse model of PDAC induces a greater number of proliferative precursor lesions coupled with a pronounced fibrotic reaction. ATM-targeted mice display altered TGFβ-superfamily signalling and enhanced epithelial-to-mesenchyma ...[more]