Ontology highlight
ABSTRACT:
SUBMITTER: Rocha NP
PROVIDER: S-EPMC4532803 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Rocha Natália Pessoa NP de Miranda Aline Silva AS Teixeira Antônio Lúcio AL
BioMed research international 20150729
Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide, being characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Among several putative factors that may contribute to PD pathogenesis, inflammatory mechanisms may play a pivotal role. The involvement of microglial activation as well as of brain and peripheral immune mediators in PD pathophysiology has been reported by clinical and experimental studies. These inflamm ...[more]