Ontology highlight
ABSTRACT:
SUBMITTER: Janzen DM
PROVIDER: S-EPMC4532886 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Janzen D M DM Tiourin E E Salehi J A JA Paik D Y DY Lu J J Pellegrini M M Memarzadeh S S
Nature communications 20150803
High-grade serous ovarian cancers (HGSCs) are deadly malignancies that relapse despite carboplatin chemotherapy. Here we show that 16 independent primary HGSC samples contain a CA125-negative population enriched for carboplatin-resistant cancer initiating cells. Transcriptome analysis reveals upregulation of homologous recombination DNA repair and anti-apoptotic signals in this population. While treatment with carboplatin enriches for CA125-negative cells, co-treatment with carboplatin and birin ...[more]