Ontology highlight
ABSTRACT:
SUBMITTER: Dong Y
PROVIDER: S-EPMC4532939 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Dong Yinhua Y Wang Hongxin H Chen Zefeng Z
International journal of endocrinology 20150729
Alpha-lipoic acid (ALA) has various pharmacological effects such as antioxidative, anti-inflammatory, and antiapoptotic properties. In the present study, administration of ALA (40 mg/kg, i.p.) for 3 days resulted in a significant decrease in neuronal deficit score and infarct volume and a significant increase in grip time and latency time in Morris water maze at 48 h after middle cerebral artery occlusion and reperfusion (MCAO/R) in rats. ALA also reduced the increased TUNEL-positive cells rate ...[more]