Ontology highlight
ABSTRACT:
SUBMITTER: Belloni E
PROVIDER: S-EPMC4533313 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Belloni Elena E Martin Padura Ines I Gerbino Elvira E Orecchioni Stefania S Fusar Imperatore Fulvia F Marighetti Paola P Bertalot Giovanni G Giuseppe Pelicci Pier P Bertolini Francesco F
Scientific reports 20150812
A role for bone-marrow-derived cells (BMDCs) in tissue repair and malignancy onset has been proposed, but their contribution is still debated. We tested the ability of BMDCs containing the inducible kras(V12) oncogene to initiate lung adenocarcinoma. For our experimental strategy, we reconstituted lethally irradiated wild type mice with BMDCs carrying inducible kras(V12) and subsequently induced oncogene expression by 4-OHT administration. Epithelial lung lesions, from adenoma to adenocarcinomas ...[more]