Adoptive immunotherapy for cancer or viruses.
Ontology highlight
ABSTRACT:
SUBMITTER: Maus MV
PROVIDER: S-EPMC4533835 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Adoptive immunotherapy for cancer or viruses.
Maus Marcela V MV Fraietta Joseph A JA Levine Bruce L BL Kalos Michael M Zhao Yangbing Y June Carl H CH
Annual review of immunology 20140109
Adoptive immunotherapy, or the infusion of lymphocytes, is a promising approach for the treatment of cancer and certain chronic viral infections. The application of the principles of synthetic biology to enhance T cell function has resulted in substantial increases in clinical efficacy. The primary challenge to the field is to identify tumor-specific targets to avoid off-tumor, on-target toxicity. Given recent advances in efficacy in numerous pilot trials, the next steps in clinical development ...[more]
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