Ontology highlight
ABSTRACT:
SUBMITTER: Rodriguez AR
PROVIDER: S-EPMC4533996 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Rodriguez Annette R AR Plascencia-Villa Germán G Witt Colleen M CM Yu Jieh-Juen JJ José-Yacamán Miguel M Chambers James P JP Perry George G Guentzel M Neal MN Arulanandam Bernard P BP
Cellular immunology 20150401 2
The human pathogen Chlamydia pneumoniae has been implicated in chronic inflammatory diseases including type 2 diabetes. Therefore, we designed a study to evaluate pancreatic beta cells and mast cells during chlamydial infection. Our study revealed that C. pneumoniae infected mast cells significantly (p<0.005) decreased beta cell ATP and insulin production, in contrast to uninfected mast cells co-cultured with beta cells. Infected mast cells exhibited pyknotic nuclei and active caspase-3 and casp ...[more]