Ontology highlight
ABSTRACT:
SUBMITTER: Tu YT
PROVIDER: S-EPMC4534351 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Tu Ya-Ting YT Barrientos Antoni A
Cell reports 20150213 6
Human mitochondrial ribosomes are specialized in the synthesis of 13 proteins, which are fundamental components of the oxidative phosphorylation system. The pathway of mitoribosome biogenesis, the compartmentalization of the process, and factors involved remain largely unknown. Here, we have identified the DEAD-box protein DDX28 as an RNA granule component essential for the biogenesis of the mitoribosome large subunit (mt-LSU). DDX28 interacts with the 16S rRNA and the mt-LSU. RNAi-mediated DDX2 ...[more]