Microbes Promote Amino Acid Harvest to Rescue Undernutrition in Drosophila.
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ABSTRACT:
SUBMITTER: Yamada R
PROVIDER: S-EPMC4534362 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Publications
Microbes Promote Amino Acid Harvest to Rescue Undernutrition in Drosophila.
Yamada Ryuichi R Deshpande Sonali A SA Bruce Kimberley D KD Mak Elizabeth M EM Ja William W WW
Cell reports 20150213 6
Microbes play an important role in the pathogenesis of nutritional disorders such as protein-specific malnutrition. However, the precise contribution of microbes to host energy balance during undernutrition is unclear. Here, we show that Issatchenkia orientalis, a fungal microbe isolated from field-caught Drosophila melanogaster, promotes amino acid harvest to rescue the lifespan of undernourished flies. Using radioisotope-labeled dietary components (amino acids, nucleotides, and sucrose) to qua ...[more]
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