Ontology highlight
ABSTRACT:
SUBMITTER: Kubota T
PROVIDER: S-EPMC4534484 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Cell reports 20150723 5
The sliding clamp PCNA is a crucial component of the DNA replication machinery. Timely PCNA loading and unloading are central for genome integrity and must be strictly coordinated with other DNA processing steps during replication. Here, we show that the S. cerevisiae Elg1 replication factor C-like complex (Elg1-RLC) unloads PCNA genome-wide following Okazaki fragment ligation. In the absence of Elg1, PCNA is retained on chromosomes in the wake of replication forks, rather than at specific sites ...[more]