Ontology highlight
ABSTRACT:
SUBMITTER: Carnio S
PROVIDER: S-EPMC4534571 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Carnio Silvia S LoVerso Francesca F Baraibar Martin Andres MA Longa Emanuela E Khan Muzamil Majid MM Maffei Manuela M Reischl Markus M Canepari Monica M Loefler Stefan S Kern Helmut H Blaauw Bert B Friguet Bertrand B Bottinelli Roberto R Rudolf Rüdiger R Sandri Marco M
Cell reports 20140828 5
The cellular basis of age-related tissue deterioration remains largely obscure. The ability to activate compensatory mechanisms in response to environmental stress is an important factor for survival and maintenance of cellular functions. Autophagy is activated both under short and prolonged stress and is required to clear the cell of dysfunctional organelles and altered proteins. We report that specific autophagy inhibition in muscle has a major impact on neuromuscular synaptic function and, co ...[more]