Ontology highlight
ABSTRACT:
SUBMITTER: Nagafuchi S
PROVIDER: S-EPMC4534683 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Nagafuchi Seiho S Kamada-Hibio Yumi Y Hirakawa Kanako K Tsutsu Nobutaka N Minami Masae M Okada Akira A Kai Katsuya K Teshima Miho M Moroishi Arisa A Murakami Yoshikazu Y Umeno Yoshikazu Y Yokogawa Yasushi Y Kogawa Kazuhiko K Izumi Kenichi K Anzai Keizo K Iwakiri Ryuichi R Hamaguchi Kazuyuki K Sasaki Nobuhiro N Nohara Sakae S Yoshida Eiko E Harada Mine M Akashi Koichi K Yanase Toshihiko T Ono Junko J Okeda Toshimitsu T Fujimoto Ryoji R Ihara Kenji K Hara Toshiro T Kikuchi Yohei Y Iwase Masanori M Kitazono Takanari T Kojima Fumiko F Kono Suminori S Kurisaki Hironori H Kondo Shiori S Katsuta Hitoshi H
EBioMedicine 20150509 7
<h4>Background</h4>Recently, natural mutation of Tyrosine kinase 2 (Tyk2) gene has been shown to determine susceptibility to murine virus-induced diabetes. In addition, a previous human genome-wide study suggested the type 1 diabetes (T1D) susceptibility region to be 19p13, where the human TYK2 gene is located (19p13.2).<h4>Methods</h4>Polymorphisms of TYK2 gene at the promoter region and exons were studied among 331 healthy controls, and 302 patients with T1D and 314 with type 2 diabetes (T2D) ...[more]