Host adaption to the bacteriophage carrier state of Campylobacter jejuni.

ABSTRACT: The carrier state of the foodborne pathogen Campylobacter jejuni represents an alternative life cycle whereby virulent bacteriophages can persist in association with host bacteria without commitment to lysogeny. Host bacteria exhibit significant phenotypic changes that improve their ability to survive extra-intestinal environments, but exhibit growth-phase-dependent impairment in motility. We demonstrate that early exponential phase cultures become synchronised with respect to the non-motile phenotype, which corresponds with a reduction in their ability to adhere to and invade intestinal epithelial cells. Comparative transcriptome analyses (RNA-seq) identify changes in gene expression that account for the observed phenotypes: downregulation of stress response genes hrcA, hspR and per and d

SUBMITTER: Brathwaite KJ 

PROVIDER: S-EPMC4534711 | biostudies-literature | 2015 Jul-Aug

REPOSITORIES: biostudies-literature