Dataset Information

Acute myeloid leukemia risk by industry and occupation.

ABSTRACT: Acute myeloid leukemia (AML) is the most common type of leukemia found in adults. Identifying jobs that pose a risk for AML may be useful for identifying new risk factors. A matched case-control analysis was conducted using California Cancer Registry data from 1988 to 2007. This study included 8999 cases of AML and 24 822 controls. Industries with a statistically significant increased AML risk were construction (matched odds ratio [mOR] = 1.13); crop production (mOR = 1.41); support activities for agriculture and forestry (mOR = 2.05); and animal slaughtering and processing (mOR = 2.09). Among occupations with a statistically significant increased AML risk were miscellaneous agricultural workers (mOR = 1.76); fishers and related fishing workers (mOR = 2.02); nursing, psychiatric and home health aides (mOR = 1.65); and janitors and building cleaners (mOR = 1.54). Further investigation is needed to confirm study findings and to identify specific exposures responsible for the increased risks.

SUBMITTER: Tsai RJ

PROVIDER: S-EPMC4534715 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature

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Acute myeloid leukemia risk by industry and occupation.

Tsai Rebecca J RJ Luckhaupt Sara E SE Schumacher Pam P Cress Rosemary D RD Deapen Dennis M DM Calvert Geoffrey M GM

Leukemia & lymphoma 20140331 11

Acute myeloid leukemia (AML) is the most common type of leukemia found in adults. Identifying jobs that pose a risk for AML may be useful for identifying new risk factors. A matched case-control analysis was conducted using California Cancer Registry data from 1988 to 2007. This study included 8999 cases of AML and 24 822 controls. Industries with a statistically significant increased AML risk were construction (matched odds ratio [mOR] = 1.13); crop production (mOR = 1.41); support activities f ...[more]

PMID: 24547710

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Project description:The role of occupation in the etiology of renal cell carcinoma (RCC) is unclear. Here, we investigated associations between employment in specific occupations and industries and RCC, and its most common histologic subtype, clear cell RCC (ccRCC).Between 2002 and 2007, a population-based case-control study of Caucasians and African Americans (1,217 cases; 1,235 controls) was conducted within the Detroit and Chicago metropolitan areas to investigate risk factors for RCC. As part of this study, occupational histories were ascertained through in-person interviews. We computed odds ratios (ORs) and 95% confidence intervals (CIs) relating occupation and industry to RCC risk using adjusted unconditional logistic regression models.Employment in the agricultural crop production industry for five years or more was associated with RCC (OR?=?3.3 [95% CI?=?1.0-11.5]) and ccRCC in particular (OR?=?6.3 [95% CI?=?1.7-23.3], P for trend with duration of employment?=?0.0050). Similarly, RCC risk was elevated for employment of five years or longer in non-managerial agricultural and related occupations (ORRCC?=?2.1 [95% CI?=?1.0-4.5]; ORccRCC?=?3.1 [95% CI?=?1.4-6.8]). Employment in the dry-cleaning industry was also associated with elevated risk (ORRCC?=?2.0 [95% CI?=?0.9-4.4], P for trend?=?0.093; ORccRCC?=?3.0 [95% CI?=?1.2-7.4], P for trend?=?0.031). Suggestive elevated associations were observed for police/public safety workers, health care workers and technicians, and employment in the electronics, auto repair, and cleaning/janitorial services industries; protective associations were suggested for many white-collar jobs including computer science and administrative occupations as well employment in the business, legislative, and education industries.Our findings provide support for an elevated risk of RCC in the agricultural and dry-cleaning industries and suggest that these associations may be stronger for the ccRCC subtype. Additional studies are needed to confirm these findings.

Dataset Information

Acute myeloid leukemia risk by industry and occupation.

Publications

Acute myeloid leukemia risk by industry and occupation.

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