A critical role of toll-like receptor 2 (TLR2) and its' in vivo ligands in radio-resistance.
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ABSTRACT:
SUBMITTER: Gao F
PROVIDER: S-EPMC4534783 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
A critical role of toll-like receptor 2 (TLR2) and its' in vivo ligands in radio-resistance.
Gao Fu F Zhang Chaoxiong C Zhou Chuanfeng C Sun Weimin W Liu Xin X Zhang Pei P Han Jiaqi J Xian Linfeng L Bai Dongchen D Liu Hu H Cheng Ying Y Li Bailong B Cui Jianguo J Cai Jianming J Liu Cong C
Scientific reports 20150813
The role of Toll-like receptor-2 (TLR2) in radio-resistance remained largely unknown. TLR2 knockout (TLR2(-/-)) mice received radiation of 6.5 Gy, and then were studied. We found that radiation resulted in more severe mortality and morbidity rates in TLR2(-/-) mice. The cause of death in TLR2(-/-) mice may be severe and persistent bone marrow cell loss. Injection of the TLR2 agonist Pam3CSK4 into wild type (WT) mice induced radio-resistance. Myd88(-/-) mice were more susceptible to radiation. In ...[more]
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