Fecal Microbiota Characteristics of Patients with Colorectal Adenoma Detected by Screening: A Population-based Study.
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ABSTRACT:
SUBMITTER: Goedert JJ
PROVIDER: S-EPMC4535156 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
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Fecal Microbiota Characteristics of Patients with Colorectal Adenoma Detected by Screening: A Population-based Study.
Goedert James J JJ Gong Yangming Y Hua Xing X Zhong Huanzi H He Yimin Y Peng Peng P Yu Guoqin G Wang Wenjing W Ravel Jacques J Shi Jianxin J Zheng Ying Y
EBioMedicine 20150418 6
<h4>Background</h4>Screening for colorectal cancer (CRC) and precancerous colorectal adenoma (CRA) can detect curable disease. However, participation in colonoscopy and sensitivity of fecal heme for CRA are low.<h4>Methods</h4>Microbiota metrics were determined by Illumina sequencing of 16S rRNA genes amplified from DNA extracted from feces self-collected in RNAlater. Among fecal immunochemical test-positive (FIT +) participants, colonoscopically-defined normal versus CRA patients were compared ...[more]
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