PARP inhibitors in the management of breast cancer: current data and future prospects.
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ABSTRACT:
SUBMITTER: Livraghi L
PROVIDER: S-EPMC4535298 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
PARP inhibitors in the management of breast cancer: current data and future prospects.
Livraghi Luca L Garber Judy E JE
BMC medicine 20150813
Poly(ADP-ribose) polymerases (PARP) are enzymes involved in DNA-damage repair. Inhibition of PARPs is a promising strategy for targeting cancers with defective DNA-damage repair, including BRCA1 and BRCA2 mutation-associated breast and ovarian cancers. Several PARP inhibitors are currently in trials in the adjuvant, neoadjuvant, and metastatic settings for the treatment of ovarian, BRCA-mutated breast, and other cancers. We herein review the development of PARP inhibitors and the basis for the e ...[more]
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