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Whole-genome resequencing analyses of five pig breeds, including Korean wild and native, and three European origin breeds.


ABSTRACT: Pigs have been one of the most important sources of meat for humans, and their productivity has been substantially improved by recent strong selection. Here, we present whole-genome resequencing analyses of 55 pigs of five breeds representing Korean native pigs, wild boar and three European origin breeds. 1,673.1 Gb of sequence reads were mapped to the Swine reference assembly, covering ?99.2% of the reference genome, at an average of ?11.7-fold coverage. We detected 20,123,573 single-nucleotide polymorphisms (SNPs), of which 25.5% were novel. We extracted 35,458 of non-synonymous SNPs in 9,904 genes, which may contribute to traits of interest. The whole SNP sets were further used to access the population structures of the breeds, using multiple methodologies, including phylogenetic, similarity matrix, and population structure analysis. They showed clear population clusters with respect to each breed. Furthermore, we scanned the whole genomes to identify signatures of selection throughout the genome. The result revealed several promising loci that might underlie economically important traits in pigs, such as the CLDN1 and TWIST1 genes. These discoveries provide useful genomic information for further study of the discrete genetic mechanisms associated with economically important traits in pigs.

SUBMITTER: Choi JW 

PROVIDER: S-EPMC4535618 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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Whole-genome resequencing analyses of five pig breeds, including Korean wild and native, and three European origin breeds.

Choi Jung-Woo JW   Chung Won-Hyong WH   Lee Kyung-Tai KT   Cho Eun-Seok ES   Lee Si-Woo SW   Choi Bong-Hwan BH   Lee Sang-Heon SH   Lim Wonjun W   Lim Dajeong D   Lee Yun-Gyeong YG   Hong Joon-Ki JK   Kim Doo-Wan DW   Jeon Hyeon-Jeong HJ   Kim Jiwoong J   Kim Namshin N   Kim Tae-Hun TH  

DNA research : an international journal for rapid publication of reports on genes and genomes 20150627 4


Pigs have been one of the most important sources of meat for humans, and their productivity has been substantially improved by recent strong selection. Here, we present whole-genome resequencing analyses of 55 pigs of five breeds representing Korean native pigs, wild boar and three European origin breeds. 1,673.1 Gb of sequence reads were mapped to the Swine reference assembly, covering ∼99.2% of the reference genome, at an average of ∼11.7-fold coverage. We detected 20,123,573 single-nucleotide  ...[more]

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