Ontology highlight
ABSTRACT:
SUBMITTER: Khan IS
PROVIDER: S-EPMC4535774 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Khan Imran S IS Park Chong Y CY Mavropoulos Anastasia A Shariat Nikki N Pollack Joshua L JL Barczak Andrea J AJ Erle David J DJ McManus Michael T MT Anderson Mark S MS Jeker Lukas T LT
PloS one 20150813 8
Thymic epithelial cells (TECs) support T cell development in the thymus. Cortical thymic epithelial cells (cTECs) facilitate positive selection of developing thymocytes whereas medullary thymic epithelial cells (mTECs) facilitate the deletion of self-reactive thymocytes in order to prevent autoimmunity. The mTEC compartment is highly dynamic with continuous maturation and turnover, but the genetic regulation of these processes remains poorly understood. MicroRNAs (miRNAs) are important regulator ...[more]