Ontology highlight
ABSTRACT:
SUBMITTER: Marques M
PROVIDER: S-EPMC4535928 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Marques Maud M Hernández Rodrigo Peña RP Witcher Michael M
Genomics data 20141018
CTCF is a key regulator of nuclear chromatin structure, chromatin organization and gene regulation. The impact of CTCF on transcriptional output is quite varied, ranging from repression, to transcriptional pausing and transactivation. The multifunctional nature of CTCF is mediated, in part, through differential association with protein partners having unique properties. We identified the general transcription factor TFII-I as an interacting partner of CTCF. To gain an understanding of the functi ...[more]