Transcriptomic profiling of trichloroethylene exposure in male mouse liver.
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ABSTRACT:
SUBMITTER: Jiang Y
PROVIDER: S-EPMC4535943 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
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Transcriptomic profiling of trichloroethylene exposure in male mouse liver.
Jiang Yan Y Chen Jiahong J Tong Jian J Chen Tao T
Genomics data 20150115
Chronic Trichloroethylene (TCE) exposure could induce hepatocellular carcinoma in mice, and occupational exposure in humans was suggested to be associated with liver cancer. To understand the role of non-genotoxic mechanism(s) for TCE action, we examined the gene expression and DNA methylation changes in the liver of B6C3F1 mice orally administered with TCE for 5 days. As a beginning step, we profiled gene expression alterations induced by the TCE in mouse livers. Here we describe in detail the ...[more]
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Project description:To examine changes, if any, in the expression of mRNAs in the liver tissue of mice, we have employed whole genome microarray expression profiling as a discovery platform to identify genes responsive to Trichloroethylene (TCE) treatment. In our results, the expression levels of 431 mRNAs were changed after TCE exposure, of which 291 were up-regulated and 140 were down-regulated. Using qPCR, we validated six of the mRNA expression changed genes, viz., Jun, Cdkn1a, Rad51b, Uhrf1, Svil and Ihh.
2014-11-14 | GSE58819 | GEO