Genome-wide profiling of alternative splicing in Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Lai MK
PROVIDER: S-EPMC4535993 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Publications
Genome-wide profiling of alternative splicing in Alzheimer's disease.
Lai Mitchell K P MK Esiri Margaret M MM Tan Michelle G K MG
Genomics data 20140907
Alternative splicing is a highly regulated process which generates transcriptome and proteome diversity through the skipping or inclusion of exons within gene loci. Identification of aberrant alternative splicing associated with human diseases has become feasible with the development of new genomic technologies and powerful bioinformatics. We have previously reported genome-wide gene alterations in the neocortex of a well-characterized cohort of Alzheimer's disease (AD) patients and matched elde ...[more]
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