Ontology highlight
ABSTRACT:
SUBMITTER: Guselnikov SV
PROVIDER: S-EPMC4536121 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Guselnikov S V SV Grayfer L L De Jesús Andino F F Rogozin I B IB Robert J J Taranin A V AV
Developmental and comparative immunology 20150711 1
The ITAM-bearing transmembrane signaling subunits (TSS) are indispensable components of activating leukocyte receptor complexes. The TSS-encoding genes map to paralogous chromosomal regions, which are thought to arise from ancient genome tetraploidization(s). To assess a possible role of tetraploidization in the TSS evolution, we studied TSS and other functionally linked genes in the amphibian species Xenopus laevis whose genome was duplicated about 40 MYR ago. We found that X. laevis has retain ...[more]