Ontology highlight
ABSTRACT:
SUBMITTER: Benaich N
PROVIDER: S-EPMC4536294 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Benaich Nathan N Woodhouse Samuel S Goldie Stephen J SJ Mishra Ajay A Quist Sven R SR Watt Fiona M FM
Cell reports 20141002 1
Metastatic colonization of distant organs underpins the majority of human-cancer-related deaths, including deaths from head and neck squamous cell carcinoma (HNSCC). We report that miR-203, a miRNA that triggers differentiation in multilayered epithelia, inhibits multiple postextravasation events during HNSCC lung metastasis. Inducible reactivation of miR-203 in already established lung metastases reduces the overall metastatic burden. Using an integrated approach, we reveal that miR-203 inhibit ...[more]