Ontology highlight
ABSTRACT:
SUBMITTER: Yoshida H
PROVIDER: S-EPMC4536312 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Yoshida Hisashi H Park Sam-Yong SY Oda Takashi T Akiyoshi Taeko T Sato Mamoru M Shirouzu Mikako M Tsuda Kengo K Kuwasako Kanako K Unzai Satoru S Muto Yutaka Y Urano Takeshi T Obayashi Eiji E
Genes & development 20150727 15
The pre-mRNA splicing reaction of eukaryotic cells has to be carried out extremely accurately, as failure to recognize the splice sites correctly causes serious disease. The small subunit of the U2AF heterodimer is essential for the determination of 3' splice sites in pre-mRNA splicing, and several single-residue mutations of the U2AF small subunit cause severe disorders such as myelodysplastic syndromes. However, the mechanism of RNA recognition is poorly understood. Here we solved the crystal ...[more]