Ontology highlight
ABSTRACT:
SUBMITTER: He F
PROVIDER: S-EPMC4536323 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
RNA (New York, N.Y.) 20150716 9
Decapping commits an mRNA to complete degradation and promotes general 5' to 3' decay, nonsense-mediated decay (NMD), and transcript-specific degradation. In Saccharomyces cerevisiae, a single decapping enzyme composed of a regulatory subunit (Dcp1) and a catalytic subunit (Dcp2) targets thousands of distinct substrate mRNAs. However, the mechanisms controlling this enzyme's in vivo activity and substrate specificity remain elusive. Here, using a genetic approach, we show that the large C-termin ...[more]