Ontology highlight
ABSTRACT:
SUBMITTER: Tsuboi K
PROVIDER: S-EPMC4536456 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Tsuboi Koichiro K Nishitani Mayo M Takakura Atsushi A Imai Yasuyuki Y Komatsu Masaaki M Kawashima Hiroto H
The Journal of biological chemistry 20150706 33
Genome-wide association studies of inflammatory bowel diseases identified susceptible loci containing an autophagy-related gene. However, the role of autophagy in the colon, a major affected area in inflammatory bowel diseases, is not clear. Here, we show that colonic epithelial cell-specific autophagy-related gene 7 (Atg7) conditional knock-out (cKO) mice showed exacerbation of experimental colitis with more abundant bacterial invasion into the colonic epithelium. Quantitative PCR analysis reve ...[more]