Ontology highlight
ABSTRACT:
SUBMITTER: Faridounnia M
PROVIDER: S-EPMC4536458 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Faridounnia Maryam M Wienk Hans H Kovačič Lidija L Folkers Gert E GE Jaspers Nicolaas G J NG Kaptein Robert R Hoeijmakers Jan H J JH Boelens Rolf R
The Journal of biological chemistry 20150617 33
The ERCC1-XPF heterodimer, a structure-specific DNA endonuclease, is best known for its function in the nucleotide excision repair (NER) pathway. The ERCC1 point mutation F231L, located at the hydrophobic interaction interface of ERCC1 (excision repair cross-complementation group 1) and XPF (xeroderma pigmentosum complementation group F), leads to severe NER pathway deficiencies. Here, we analyze biophysical properties and report the NMR structure of the complex of the C-terminal tandem helix-ha ...[more]