Ontology highlight
ABSTRACT:
SUBMITTER: Duan C
PROVIDER: S-EPMC4536492 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Duan Cuimi C Yang Xiqin X Zhang Xuhui X Feng Jiannan J Liu Zhiqiang Z Que Haiping H Johnson Heather H Zhao Yanfeng Y Fan Yawen Y Lu Yinglin Y Zhang Heqiu H Huang Yan Y Xiu Bingshui B Feng Xiaoyan X
Scientific reports 20150814
Mammaglobin A (MGA) is an organ specific molecular biomarker for metastatic breast cancer diagnosis. However, there are still needs to develop optimal monoclonal antibodies (mAbs) to detect MGA expression in breast carcinoma by immunohistochemistry. In this study, we first generated mAbs against MGA. Then, we used epitope prediction and computer-assisted structural analysis to screen five dominant epitopes and identified mAbs against five epitopes. Further immunohistochemical analysis on 42 brea ...[more]