Ontology highlight
ABSTRACT:
SUBMITTER: Dennis M
PROVIDER: S-EPMC4536889 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Dennis Mike M Russell Nigel N Hills Robert K RK Hemmaway Claire C Panoskaltsis Nicki N McMullin Mary-Frances MF Kjeldsen Lars L Dignum Helen H Thomas Ian F IF Clark Richard E RE Milligan Don D Burnett Alan K AK
Blood 20150324 19
The development of new treatments for older patients with acute myeloid leukemia is an active area, but has met with limited success. Vosaroxin, a quinolone-derived intercalating agent has several properties that could prove beneficial. Initial clinical studies showed it to be well-tolerated in older patients with relapsed/refractory disease. In vitro data suggested synergy with cytarabine (Ara-C). To evaluate vosaroxin, we performed 2 randomized comparisons within the "Pick a Winner" program. A ...[more]