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Design of Thiol- and Light-sensitive Degradable Hydrogels using Michael-type Addition Reactions.

ABSTRACT: Injectable depots that respond to exogenous and endogenous stimuli present an attractive strategy for tunable, patient-specific drug delivery. Here, the design of injectable and multimodal degradable hydrogels that respond to externally applied light and physiological stimuli, specifically aqueous and reducing microenvironments, is reported. Rapid hydrogel formation was achieved using a thiol-maleimide click reaction between multifunctional poly(ethylene glycol) macromers. Hydrogel degradation kinetics in response to externally applied cytocompatible light, reducing conditions, and hydrolysis were characterized, and degradation of the gel was controlled over multiple time scales from seconds to days. Further, tailored release of an encapsulated model cargo, fluorescent nanobeads, was demonstrated.

SUBMITTER: Kharkar PM

PROVIDER: S-EPMC4536978 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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Design of Thiol- and Light-sensitive Degradable Hydrogels using Michael-type Addition Reactions.

Kharkar Prathamesh M PM Kiick Kristi L KL Kloxin April M AM

Polymer chemistry 20150801 31

Injectable depots that respond to exogenous and endogenous stimuli present an attractive strategy for tunable, patient-specific drug delivery. Here, the design of injectable and multimodal degradable hydrogels that respond to externally applied light and physiological stimuli, specifically aqueous and reducing microenvironments, is reported. Rapid hydrogel formation was achieved using a thiol-maleimide click reaction between multifunctional poly(ethylene glycol) macromers. Hydrogel degradation k ...[more]

PMID: 26284125

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